Imidapril

Overview

Imidapril (TA-6366 free base) is an orally active dual inhibitor of angiotensin-converting enzyme ( ACE ) and MMP-9 . Imidapril inhibits lipopolysaccharide-induced phosphorylation of c-Jun , MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10 , thereby exerting anti-inflammatory activity. Imidapril also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.

Application

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Product Information

• Catalog No.: HY-B1451A
• CAS No.: 89371-37-9
• Molecular Formula: C20H27N3O6
• Molecular Weight: 405.44
• Purity: 99.0%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.25 mg/mL (3.08 mM); Clear solution
• Availability: In-stock

Source

Original product source