Gedunin

Overview

Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). It also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | Hsp90

Product Information

• Catalog No.: B0084-272120
• CAS No.: 2753-30-2
• Molecular Formula: C28H34O7
• Molecular Weight: 482.57
• Purity: >98%
• Storage: Store at 4 °C
• Solubility: DMSO: 100 mg/mL; Ethanol: 10 mg/mL with gentle warming

Source

Original product source