Sulindac sulfone

Overview

Sulindac sulfone is an orally active metabolite of Sulindac ( HY-B0008 ). Sulindac sulfone activates PPARγ and drives transcriptional induction of SSAT by binding to the PPRE-2 element. Sulindac sulfone induces Apoptosis . Sulindac sulfone negatively regulates the function of VDAC1/2 to inhibit the mTORC1 pathway, reduces Cyclin D1 levels, and induces G 1 cell cycle arrest in colon cancer cells. Sulindac sulfone exerts colon cancer preventive effects through a COX -independent mechanism. Sulindac sulfone can be used in research related to colon cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-B1787
• CAS No.: 59973-80-7
• Molecular Formula: C20H17FO4S
• Molecular Weight: 372.41
• Purity: 98.10%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source