Adaphostin

Overview

Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210 bcr/abl inhibitor ( IC 50 =14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC 50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells.

Application

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Product Information

• Catalog No.: HY-103275
• CAS No.: 241127-58-2
• Molecular Formula: C24H27NO4
• Molecular Weight: 393.48
• Purity: 99.02%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
• Availability: In-stock

Source

Original product source