PD176252

Overview

PD176252 is a potent antagonist of neuromedin-B preferring ( BB 1 ) and gastrin-releasing peptide-preferring ( BB 2 ) receptor with K i s of 0.17 nM and 1 nM for human BB 1 and BB 2 receptors, and 0.66 nM, 16 nM for Rat BB 1 and BB 2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 ( FPR1/FPR2 ), with EC 50 s of 0.31 and 0.66 μM in HL-60 cells.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bombesin Receptor

Product Information

• Catalog No.: HY-103286
• CAS No.: 204067-01-6
• Molecular Formula: C32H36N6O5
• Molecular Weight: 584.67
• Purity: 99.38%
• Storage: 4°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: 5.75 mg/mL (9.83 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source