J-113863

Overview

J-113863 is a potent and selective CCR1 antagonist with IC 50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 ( IC 50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 ( IC 50 of 460 nM). J-113863 is inactive against CCR2 , CCR4 and CCR5 , as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Pain | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CCR

Product Information

• Catalog No.: HY-103360
• CAS No.: 353791-85-2
• Molecular Formula: C30H37Cl2IN2O2
• Molecular Weight: 655.44
• Purity: 95.19%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.81 mM); Clear solution
• Availability: In-stock

Source

Original product source