C-021

Overview

C-021 is a potent CC chemokine receptor-4 ( CCR4 ) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC 50 s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [ 35 S]GTPγS from binding to the receptor with an IC 50 of 18 nM.

Application

Products | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CCR

Product Information

• Catalog No.: HY-103364
• CAS No.: 864289-85-0
• Molecular Formula: C27H41N5O2
• Molecular Weight: 467.65
• Purity: 99.95%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 0.71 mg/mL (1.52 mM); Clear solution
• Availability: In-stock

Source

Original product source