N-Desmethyl imatinib

Overview

N‑Desmethyl imatinib (Norimatinib) is an active metabolite of Imatinib ( HY-15463 ), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein . N-Desmethyl imatinib binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib shows significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) models with mild SARS-CoV-2 infection . N-Desmethyl imatinib can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.

Application

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Product Information

• Catalog No.: HY-G0017
• CAS No.: 404844-02-6
• Molecular Formula: C28H29N7O
• Molecular Weight: 479.59
• Purity: 98.33%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.21 mM); Clear solution
• Availability: In-stock

Source

Original product source