Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC 50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA . Ginsenoside Rd also inhibits Ca 2+ influx. Ginsenoside Rd inhibits CYP2D6 , CYP1A2 , CYP3A4 , and CYP2C9 , with IC 50 s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
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