L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase ( eNOS ) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.
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