Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 ( PD-L1 ) expression. Panaxadiol shows anticancer , cardioprotective, anti-arrhythmic, and antioxidative activities.
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