Isobavachin

Overview

Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia . Isobavachin inhibits human CYP2B6 , CYP2C9 , CYP2C19 , UGT1A1 , UGT1A9 , and UGT2B7 . Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2 , FcεRI -mediated signaling pathways, and RANKL -induced osteoclastogenesis. Isobavachin induces autophagy , cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis , iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer , prostate cancer , glioma, periodontitis-induced bone loss, and Alzheimer's disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Liver Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Glioma | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Antioxidant Agent | Products > Disease Areas > Liver Injury | Products > Disease Areas > Osteoarthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > COX | Products > Signaling Pathways > Fc Receptor (FcR) | Products > Signaling Pathways > RANKL/RANK | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > UGT

Product Information

• Catalog No.: HY-N0762
• CAS No.: 31524-62-6
• Molecular Formula: C20H20O4
• Molecular Weight: 324.37
• Purity: 99.88%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.71 mM); Clear solution
• Availability: In-stock

Source

Original product source