Isofraxidin, a coumarin component from Acanthopanax senticosus , inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells. Isofraxidin attenuates the expression of iNOS and COX-2 , Isofraxidinalso inhibits TLR4 /myeloid differentiation protein-2 (MD-2) complex formation.
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