Alisol B

Overview

Alisol B is a triterpene with diverse biological activities. Alisol B binds human soluble epoxide hydrolase ( sEH ) with a K i of 5.97 μM and reduces sEH activity. Alisol B inhibits RANKL-induced JNK phosphorylation, NFATc1 and c-Fos expression, osteoclast formation, mature osteoclast pit-forming and actin ring activity, and SERCA pump activity . Alisol B induces calcium mobilization, CaMKK-AMPK-mTOR pathway activation, autophagic flux , autophagosome formation, G 1 phase cell cycle arrest, endoplasmic reticulum stress, unfolded protein responses, and cancer cell apoptosis . Alisol B can be used for the research of hypercalcemia, osteoporosis, rheumatoid arthritis, periodontitis, acute kidney injury, and breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Luminal Breast Cancer | Products > Disease Areas > Osteoporosis | Products > Disease Areas > Hypercalcemia | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Epoxide Hydrolase | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N0805A
• CAS No.: 18649-93-9
• Molecular Formula: C30H48O4
• Molecular Weight: 472.70
• Purity: 99.57%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: 2.5 mg/mL (5.29 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source