Sweroside

Overview

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis , NLRP3 inflammasome, SIRT1 , NF-κB , AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1 , and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields.

Application

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Product Information

• Catalog No.: HY-N0806
• CAS No.: 14215-86-2
• Molecular Formula: C16H22O9
• Molecular Weight: 358.34
• Purity: 99.76%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.98 mM); Clear solution
• Availability: In-stock

Source

Original product source