Resibufogenin is an orally active anticancer agent. Resibufogenin can be extracted from toad venom. Resibufogenin blocks signaling pathways such as PI3K/Akt , NF-κB , AP-1 , activates GSK-3β , and regulates cyclin D1 . Resibufogenin can activate central neurons. Resibufogenin has anti-inflammatory activity. Resibufogenin has anti-tumor effects on a variety of tumors such as multiple myeloma, renal cancer , colorectal cancer , pancreatic cancer , and glioma.
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