SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor ( IC 50 : 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects.
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