Isoandrographolide

Overview

Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and AKT / GSK-3β / β-catenin pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3 , ASC , and caspase-1 , and reduces the levels of phosphorylated AKT , phosphorylated GSK-3β , and β-catenin . Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Fatty Liver Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Akt | Products > Signaling Pathways > GSK-3

Product Information

• Catalog No.: HY-N10359
• CAS No.: 4176-96-9
• Molecular Formula: C20H30O5
• Molecular Weight: 350.45
• Purity: 98.34%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution
• Availability: In-stock

Source

Original product source