Withaphysalin A

Overview

Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS ( HY-D1056 )-induced nuclear translocation of NF-κB p65 , as well as phosphorylation of STAT3 , ERK , JNK and p38 MAPK . Withaphysalin A upregulates the expression of HO-1 . Withaphysalin A inhibits LPS-induced production of NO , PGE 2 , IL-1β , IL-6 and TNF-α . Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2 . Withaphysalin A interacts with B-cell activating factor protein ( BAFF ) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > PERK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > PGE synthase | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > COX | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-N11011
• CAS No.: 57423-72-0
• Molecular Formula: C28H34O6
• Molecular Weight: 466.57
• Purity: 98%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source