QC6352

Overview

QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC 50 s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC 50 of 750 nM (KDM5B).

Application

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Product Information

• Catalog No.: HY-104048
• CAS No.: 1851373-36-8
• Molecular Formula: C24H25N3O2
• Molecular Weight: 387.47
• Purity: 99.13%
• Storage: 4°C, protect from light * In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)
• Solubility: ≥ 1.67 mg/mL (4.31 mM); Clear solution
• Availability: In-stock

Source

Original product source