Talmapimod

Overview

Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC 50 of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα , IL-1β , IL-6 , and VEGF ) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis . Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome).

Application

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Product Information

• Catalog No.: HY-10406
• CAS No.: 309913-83-5
• Molecular Formula: C27H30ClFN4O3
• Molecular Weight: 513.00
• Purity: 98.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.5 mg/mL (4.87 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source