Fedratinib

Overview

Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC 50 s of 3 nM for both JAK2 and JAK2V617F kinase . Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3 , respectively. Fedratinib induces cancer cell apoptosis and has the potential for myeloproliferative disorders research.

Application

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Product Information

• Catalog No.: HY-10409
• CAS No.: 936091-26-8
• Molecular Formula: C27H36N6O3S
• Molecular Weight: 524.68
• Purity: 99.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (3.96 mM); Clear solution
• Availability: In-stock

Source

Original product source