COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus . COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells ( IC 50 = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Glyoxalase (GLO)
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