Sennoside

Overview

Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna ( Cassia angustifolia ). Sennoside induces overexpression of wild-type p53 and p21 / WAF as part of pathways mediating colonic epithelial cell apoptosis . Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli , and colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Constipation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Endocrinology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PAK

Product Information

• Catalog No.: HY-N12281
• CAS No.: 517-43-1
• Molecular Formula: C42H38O20
• Molecular Weight: 862.74
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source