Scoulerine

Overview

Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and α1D- adrenergic receptor , disrupts microtubule structure, and induces cell cycle arrest and apoptosis . Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1 , and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial , antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax , Bcl-2 and cytochrome c ). Scoulerine is applicable to research related to leukemia, ovarian cancer , and colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > GABA Receptor | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Adrenergic Receptor | Products > Signaling Pathways > Beta-secretase | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-N1255
• CAS No.: 6451-73-6
• Molecular Formula: C19H21NO4
• Molecular Weight: 327.37
• Purity: 99.99%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.08 mg/mL (6.35 mM); Clear solution
• Availability: In-stock

Source

Original product source