Rhamnocitrin

Overview

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1 , NFATc3 and MAPK pathways and can scavenge DPPH ( IC 50 =28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1 -mediated store-operated calcium entry ( SOCE ), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6 , IL-8 ) and adhesion molecules (such as ICAM-1 , VCAM-1 ). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells).

Application

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Product Information

• Catalog No.: HY-N1353
• CAS No.: 569-92-6
• Molecular Formula: C16H12O6
• Molecular Weight: 300.26
• Purity: 99.29%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.08 mg/mL (6.93 mM); Clear solution
• Availability: In-stock

Source

Original product source