(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene found in Abies georgei . (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a nuclear factor kappa B ( NF-κB ) inhibitor that inhibits TNFα-triggered NF-κB activity (IC 50 = 8.7 μg/mL). (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol exhibits anti-inflammatory activity and can inhibit NO production. (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol shows significant cytotoxicity against tumor cells.
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