NLG-919

Overview

NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs).

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cancer | IDO

Product Information

• Catalog No.: B0084-462741
• CAS No.: 1402836-58-1
• Molecular Formula: C18H22N2O
• Molecular Weight: 282.38
• Purity: > 98%
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• Solubility: DMSO 15 mg/mL heating; Water < 1 mg/ml

Source

Original product source