β-Carotene-15,15'-epoxide

Overview

β-carotene-15,15ʹ-epoxide is a XIAP antagonist with apoptosis -inducing and antitumor activity, found in the leaves of Spondias mombin . In a DMBA ( HY-W011845 )-induced rat model of breast cancer , β-carotene-15,15ʹ-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP , blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis . In addition, β-carotene-15,15ʹ-epoxide significantly downregulates the expression of BCL-2 , COX-2 , and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15ʹ-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IAP | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > COX | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N15378
• CAS No.: 132541-62-9
• Molecular Formula: C40H56O
• Molecular Weight: 552.87
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source