Americanin A

Overview

Americanin A is a Neolignan. Americanin A can be isolated from the seeds of Phytolacca americana . Americanin A activates ATM and ATR , initiating the subsequent signal transduction cascades that include Chk1 , Chk2 , and tumor suppressor p53 . Americanin A targets selectively Skp2 for degradation and thereby stabilizes p27 . Americanin A suppresses the activity of Cyclin B1 and its partner cdc2 to prevent entry into Mitosis . Americanin A induces Apoptosis by producing excessive ROS . Americanin A has anti-cancer activity against colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > E1/E2/E3 Enzyme | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > ATM/ATR | Products > Signaling Pathways > Checkpoint Kinase (Chk)

Product Information

• Catalog No.: HY-N18301
• CAS No.: 69506-79-2
• Molecular Formula: C18H16O6
• Molecular Weight: 328.32
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source