Caudatin

Overview

Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis , autophagy , ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP , caspase-3 , -7 , -9 , upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic Bcl-2 and Bcl-XL . Caudatin suppresses VEGF , FAK phosphorylation, upregulates p21 , p27 , DR 5 protein expression, activates the p38 MAPK , JNK and PPARα/TFEB -mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer , inflammation and neurological disease , such as glioma and Alzheimer's disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Glioma | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > FAK | Products > Signaling Pathways > WDR5 | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > JNK | Products > Signaling Pathways > PPAR

Product Information

• Catalog No.: HY-N1983
• CAS No.: 38395-02-7
• Molecular Formula: C28H42O7
• Molecular Weight: 490.63
• Purity: 99.95%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution
• Availability: In-stock

Source

Original product source