Cucurbitacin IIa

Overview

Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC 50 of 1.455 nM against human EGFR . Cucurbitacin IIa induces caspase-3 -dependent apoptosis , downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > MEK | Products > Signaling Pathways > Raf | Products > Signaling Pathways > ERK | Products > Signaling Pathways > STAT | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > Survivin

Product Information

• Catalog No.: HY-N1988
• CAS No.: 58546-34-2
• Molecular Formula: C32H50O8
• Molecular Weight: 562.73
• Purity: 99.90%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution
• Availability: In-stock

Source

Original product source