Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3 , PI3K-Akt, mTOR and BRD4 , and inhibits the viral protein R ( Vpr ). Bellidifolin induces cell cycle arrest and apoptosis , exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer , non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury.
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