Sotetsuflavone

Overview

Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute . Sotetsuflavone inhibits phosphorylation of PI3K , Akt , mTOR , JNK , and p38 MAPK ; modulates expression of Cyclin D1, CDK4 , Bcl-2 , Bax , cleaved caspases 3/9 , MMP-9 , TGF-β , STAT3 , and β-catenin . Sotetsuflavone induces G 0 /G 1 cell cycle arrest, apoptosis , autophagy , and intracellular ROS elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Crohn's Disease | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > JNK | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > CDK | Products > Signaling Pathways > MMP | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > STAT | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-N2199
• CAS No.: 2608-21-1
• Molecular Formula: C31H20O10
• Molecular Weight: 552.48
• Purity: 99.98%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Source

Original product source