Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC 50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria , with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.
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