Polyphyllin H

Overview

Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla . Polyphyllin H potently inhibits the activities of CYP1A2 ( IC 50 = 6.44 μM, competitive), CYP2D6 ( IC 50 = 13.88 μM, competitive) and CYP3A4 ( IC 50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3 . Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel.

Application

Products | Products > Disease Areas > Hypercholesterolemia | Products > Disease Areas > Cancer | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > P-glycoprotein

Product Information

• Catalog No.: HY-N2382
• CAS No.: 81917-50-2
• Molecular Formula: C44H70O17
• Molecular Weight: 871.02
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (2.87 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source