Periplogenin

Overview

Periplogenin is an orally active cardiac glycoside found in Cortex periplocae . Periplogenin can induce ROS production and necroptosis and cause G0/G1 phase arrest. Periplogenin can inhibit pyroptosis by regulating the NLRP3/Caspase-1/GSDMD signaling. Periplogenin suppresses growth of prostate carcinoma cells by docking to an ATP1A1 protein pocket and forming a hydrogen bond with T804. Periplogenin can be used for the researches of cancer , inflammation and immunology, such as prostate carcinoma, rheumatoid arthritis and psoriasis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Depression | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-N2414
• CAS No.: 514-39-6
• Molecular Formula: C23H34O5
• Molecular Weight: 390.51
• Purity: 99.34%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
• Availability: In-stock

Source

Original product source