Flavokawain C

Overview

Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK , suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27 , downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis . Flavokawain C downregulates FABP4 , induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2 , and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1 . Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK , PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer , colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Nasopharyngeal Cancer | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > JNK | Products > Signaling Pathways > PERK | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PARP | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > IAP | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > SOD | Products > Signaling Pathways > FABP | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > GLUT | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > HSP | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-N2445
• CAS No.: 37308-75-1
• Molecular Formula: C17H16O5
• Molecular Weight: 300.31
• Purity: 99.53%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.25 mg/mL (4.16 mM); Clear solution
• Availability: In-stock

Source

Original product source