Artocarpin is an orally active apoptosis inducer . Artocarpin targets NF-κB , Erk1/2 , p38 MAPK , AktS473 , p53 , Akt 1 kinase and Akt 2 kinase . Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities.
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