Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos . Polyporenic acid C causes the cleavage of caspase-8 and caspase-3 , as well as the cleavage of PARP . Polyporenic acid C reduces the phosphorylation level of Akt (Ser473) , increases the phosphorylation of PTEN and p53 (Ser15) , and activates JNK . Polyporenic acid C induces Apoptosis . Polyporenic acid C shows anticancer activity against non-small cell lung cancer .
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