Pinusolide

Overview

Pinusolide is an AMPK activator and PAF receptor antagonist. Pinusolide activates AMPK , phosphorylates ACC , enhances IRS-1 tyrosine phosphorylation, boosts glucose uptake, and modulates insulin signaling . Pinusolide inhibits caspase-3/7 activation, intracellular calcium elevation, reactive oxygen species overproduction, lipid peroxidation, and tumor cell proliferation. Pinusolide stabilizes superoxide dismutase activity, reduces apoptotic hallmarks, induces mitochondrial pathway apoptosis , and triggers DNA fragmentation. Pinusolide can be used for the research of type 2 diabetes, neurodegenerative diseases, acute lymphoblastic leukemia, acute myeloid leukemia, and Burkitt lymphoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Blood Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Acute Lymphoblastic Leukemia | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Platelet-activating Factor Receptor (PAFR) | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-N3055
• CAS No.: 31685-80-0
• Molecular Formula: C21H30O4
• Molecular Weight: 346.46
• Purity: 99.93%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source