Glaucine

Overview

Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 ( PDE4 ), with a K i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels . Additionally, Glaucine inhibits the activation of NF-κB , leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

Application

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Product Information

• Catalog No.: HY-N3945
• CAS No.: 475-81-0
• Molecular Formula: C21H25NO4
• Molecular Weight: 355.43
• Purity: 99.55%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.03 mM); Clear solution
• Availability: In-stock

Source

Original product source