Platycodin D2

Overview

Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum . Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy , inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ , and Th2 cytokines IL-4 and IL-10 , enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy , and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer , inflammation and immunology.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-N4087
• CAS No.: 66663-90-9
• Molecular Formula: C63H102O33
• Molecular Weight: 1387.46
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution
• Availability: In-stock

Source

Original product source