Bullatine A

Overview

Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/ apoptosis and P2X receptor -mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6 . Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS ( HY-D1056 )-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression.

Application

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Product Information

• Catalog No.: HY-N5025
• CAS No.: 1354-84-3
• Molecular Formula: C22H33NO2
• Molecular Weight: 343.50
• Purity: 98.0%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source