Aspulvinone O

Overview

Aspulvinone O is a selective inhibitor of glutamate oxaloacetate aminotransferase GOT1 . Aspulvinone O inhibits glutamine metabolism and reduces NADPH production, thereby inducing oxidative stress and apoptosis in pancreatic ductal adenocarcinoma (PDAC) cells. Aspulvinone O inhibits PDAC cell proliferation in vitro and tumor growth in xenograft models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Aminotransferases (Transaminases) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N6237
• CAS No.: 914071-54-8
• Molecular Formula: C27H28O6
• Molecular Weight: 448.51
• Purity: 96.0%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source