Hellebrigenin

Overview

Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway ( ERK , p38 , JNK ) and XIAP , and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins ( Bcl-2 , Bcl-xL ) and upregulate pro-apoptotic proteins ( Bax , Bak ). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers.

Application

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Product Information

• Catalog No.: HY-N6576
• CAS No.: 465-90-7
• Molecular Formula: C24H32O6
• Molecular Weight: 416.51
• Purity: 99.69%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 1.25 mg/mL (3.00 mM); Clear solution
• Availability: In-stock

Source

Original product source