Isocryptotanshinone

Overview

Isocryptotanshinone is a dual STAT3 and PTP1B ( IC 50 = 56.1 μM) inhibitor. Isocryptotanshinone inhibits STAT3 by binding to the STAT3 SH2 domain to block phosphorylation and nuclear translocation [1][2] . Isocryptotanshinone exerts its anti-proliferative effect via the induction of cell cycle arrest, apoptosis , and pro-death autophagy , through the regulation of STAT3 , AKT/mTOR and MAPK signaling pathways. Isocryptotanshinone suppresses the xenograft gastric cancer (GC) tumor growth in BALB/c nude mice. Isocryptotanshinone can be used for cancer research, such as lung cancer , breast cancer and GC.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > JAK | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Survivin | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Atg8/LC3 | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-N6651
• CAS No.: 22550-15-8
• Molecular Formula: C19H20O3
• Molecular Weight: 296.36
• Purity: 98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source