Okadaic acid

Overview

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A ( IC 50 =0.1-0.3 nM), and inhibits PP1 ( IC 50 =15-50 nM), PP3 ( IC 50 =3.7-4 nM), PP4 ( IC 50 =0.1 nM), PP5 ( IC 50 =3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-N6785
• CAS No.: 78111-17-8
• Molecular Formula: C44H68O13
• Molecular Weight: 805.00
• Purity: 98.0%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source