Groenlandicine

Overview

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor ( AChE ( IC 50 = 0.54 μM), BChE ( IC 50 = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 ( IC 50 = 19.68 μM, K i = 21.2) and inhibits RLAR ( IC 50 = 140.1 μM), HRAR ( IC 50 = 154.2 μM), and total ROS generation ( IC 50 = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis . Groenlandicine inhibits the tumor growth when combined with Cisplatin ( HY-17394 ). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .

Application

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Product Information

• Catalog No.: HY-N6865
• CAS No.: 38691-95-1
• Molecular Formula: C19H16NO4+
• Molecular Weight: 322.34
• Purity: 99.72%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source