Iminostilbene

Overview

Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 ( Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3 , reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β , IL-6 , TNF-α , and MCP-1 , thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases.

Application

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Product Information

• Catalog No.: HY-N7064
• CAS No.: 256-96-2
• Molecular Formula: C14H11N
• Molecular Weight: 193.25
• Purity: 99.66%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (12.94 mM); Clear solution
• Availability: In-stock

Source

Original product source